Effect of Traditional Chinese Medicine Poge Heart‐Saving Decoction on Cardiac Function in Heart Failure Rat Model

作者：Lei Liu, Yanfei Mo, Bingying Wu, Zongliang Yu, Sun Bugao · 发表于：Evidence-based Complementary and Alternative Medicine · 年份：2020 · DOI：10.1155/2020/8762509 · 被引用次数：10 · 研究领域：Cardiac Fibrosis and Remodeling、Traditional Chinese Medicine Analysis、Cardiovascular Function and Risk Factors

Background . Poge heart‐saving decoction (PHSD) has been used as a medicine treating heart failure in China for many years. The study aimed to explore the effect of PHSD on cardiac function in heart failure conditions and its underlying mechanism. Methods . Adriamycin was used to induce the model of heart failure (HF) in rats. Sixty rats were randomly divided into six groups: blank control group, sham group, 9.33 g/kg group (low‐PHSD, test group), 13.995 g/kg group (moderate‐PHSD, test group), 18.66 g/kg group (high‐PHSD, test group), and fosinopril group (4.67 mg/kg, comparison test group). Cardiac ultrasound was used to evaluate the cardiac function of the rats, and radioimmunoassay was used to measure aldosterone (ALD) and angiotensin II (AngII) levels in the serum. Results . Compared with the blank control group, the left ventricular end‐diastolic dimension (LVEDd) and left ventricular end‐systolic dimension (LVEDs) in the sham group were increased (1.04 ± 0.12 vs. 0.67 ± 0.13 cm; 0.75 ± 0.13 vs. 0.28 ± 0.10 cm; P < 0.05), and the left ventricular ejection fraction was decreased (36.65 ± 5.74 vs. 76.09 ± 4.23%; P < 0.05). The ejection fraction of HF rats was increased in 9.33 g/kg group, 13.995 g/kg group, and 18.66 g/kg group compared with those of the sham group (57.13 ± 1.63, 58.43 ± 1.98, and 59.21 ± 1.37 vs. 36.65 ± 5.74%; P < 0.05). PHSD also improved cardiac function by reducing the LVEDd and LVEDs (0.88 ± 0.11, 0.75 ± 0.13, and 0.72 ± 0.18 vs. 1.04 ± 0.12...