Synthesis of Dihydroquinolines as Scaffolds for Fluorescence Sensing of Hydroxyl Radical

作者：Yalan Wu, Wenyi Huang, Danfeng Peng, Xinan Huang, Jiangyong Gu, Shengjun Wu, Tao Deng, Fang Liu · 发表于：Organic Letters · 年份：2020 · DOI：10.1021/acs.orglett.0c03852 · 被引用次数：41 · 研究领域：Molecular Sensors and Ion Detection、Luminescence and Fluorescent Materials、Radical Photochemical Reactions

A mild synthetic method to prepare dihydroquinolines has been presented. These dihydroquinolines, for the first time, showed great potential for fluorescence detection of the important biorelevant hydroxyl radicals ( • OH). Sensitive and selective • OH detection and intracellular organelle-targeted fluorescence imaging of • OH have been demonstrated by using one of the synthetic dihydroquinolines. Moreover, dihydroquinoline has also exhibited promising potential to construct advanced fluorescence probes for • OH with tunable photophysical properties.