CT-derived abdominal adiposity: Distributions and better predictive ability than BMI in a nationwide study of 59,429 adults in China

作者：Qiang Zeng, Ling Wang, Sheng-Yong Dong, Xiaojuan Zha, Limei Ran, Yongli Li, Shuang Chen, Jianbo Gao, Shaolin Li, Yong Lü, Yuqin Zhang, Xigang Xiao, Yuehua Li, Xiao Ma, Xiangyang Gong, Wei Chen, Ying‐Ying Yang, Xia Du, Bairu Chen, Yinru Lv, Yan Wu, Guobin Hong, Yaling Pan, Jun Jiao, Yan Yan, Huijuan Qi, Jian Zhai, Kai Li, Kaiping Zhao, Jing Wu, Shiwei Liu, Glen M. Blake, Haihong Fu, Xiaoxia Fu, Zhiping Guo, Isabelle Lemieux, Jean‐Pierre Després, Xiaoguang Cheng · 发表于：Metabolism · 年份：2020 · DOI：10.1016/j.metabol.2020.154456 · 被引用次数：75 · 研究领域：Cardiovascular Disease and Adiposity、Adipokines, Inflammation, and Metabolic Diseases、Diabetes, Cardiovascular Risks, and Lipoproteins

Background Although abdominal adiposity is associated with an altered cardiometabolic risk profile, the specific contribution of abdominal adipose tissue distribution remains not fully understood. Computed tomography (CT) is a well-established and precise method to measure abdominal adipose tissue distribution. The present study investigated abdominal adiposity assessed by CT in a large-scale Chinese population. Method A total of 59,429 adults who underwent a low dose chest CT for lung cancer screening at one of 13 health checkup centers throughout China were evaluated. Abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) areas were measured at the center of the 2nd lumbar vertebra with Mindways quantitative CT software using the existing CT dataset without any additional radiation exposure. The ratio of visceral to total adipose tissue (TAT) areas (VAT/TAT ratio) was calculated and expressed as a percentage. Anthropometric indices including body mass index (BMI) and waist circumference were also obtained. Results BMI, waist circumference, VAT area, SAT area, and the VAT/TAT ratio were 25.0 ± 3.0 kg/m 2 , 90 ± 8 cm, 194 ± 77 cm 2 , 85 ± 41 cm 2 , and 69.5 ± 9.1%, respectively, in men and 23.3 ± 3.1 kg/m 2 , 79 ± 8 cm, 120 ± 57 cm 2 , 123 ± 53 cm 2 , and 48.9 ± 9.7% in women. With increasing age, VAT area and the VAT/TAT ratio increased in both sexes whereas SAT area decreased in men (P < 0.001 for all). After adjustment for BMI and waist circumference...