MBD2 serves as a viable target against pulmonary fibrosis by inhibiting macrophage M2 program

作者：Yi Wang, Lei Zhang, Guorao Wu, Qing Zhou, Huihui Yue, Lizong Rao, Ting Yuan, Biwen Mo, Faxi Wang, Longmin Chen, Fei Sun, Jia Song, Fei Xiong, Shu Zhang, Qilin Yu, Ping Yang, Yongjian Xu, Jianping Zhao, Huilan Zhang, Weining Xiong, Cong‐Yi Wang · 发表于：Science Advances · 年份：2021 · DOI：10.1126/sciadv.abb6075 · 被引用次数：233 · 研究领域：Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis、Medical Imaging and Pathology Studies、Neonatal Respiratory Health Research

siRNA protected mice from BLM-induced lung injuries and fibrosis. Together, our data support the possibility that MBD2 could be a viable target against PF in clinical settings.