Coronavirus Disease 2019 Induced Inflammatory Response are Associated with Changes in Lipid Profiles

作者：Chuanwei Li, Wen Zhang, Chunmei Xu, Tan H, Guoqiang Cao, Li Li, Qidi Sun, Gengze Wu, Mingdong Hu, Shuang Wu, Qi Li, Guansong Wang, Xiaohua Zhang, C. Zeng · 年份：2020 · DOI：10.21203/rs.3.rs-64766/v1 · 被引用次数：2 · 研究领域：COVID-19 Clinical Research Studies、Adipokines, Inflammation, and Metabolic Diseases、Vitamin C and Antioxidants Research

Abstract Background: Previous studies have found some evidence of association between changes in lipids and lipoprotein and viral pneumonia. No data are available about the effect of coronavirus disease 2019 (Covid-19) on lipids. The aim of this study was to investigate the relationships between lipid profiles and inflammation markers among patients with Covid-19. Methods: In this retrospective analysis, Covid-19 patients in Jin-yin-tan Hospital and healthy individuals from Daping Hospital were enrolled. The clinical and biochemical characteristics of Covid-19 patients and healthy controls were compared. We correlated lipid parameters to disease severity and inflammatory markers. The severity of Covid-19 for all patients were stipulated according to the diagnostic and treatment guideline for Covid-19 issued by Chinese National Health Committee (the 7th edition). Results: A total of 242 Covid-19 patients and 242 sex-age matched controls were enrolled. Compared with controls, Covid-19 patients had lower lymphocyte counts as well as total cholesterol (TC), high density lipoprotein (HDL-c), low density lipoprotein cholesterol (LDL-c), non-high density lipoprotein cholesterol (non-HDL-c) and apoA-I levels on admission. Whereas apolipoprotein B (apoB) and apoB/apoA-I ratio were slightly higher in patients with Covid-19. There was no difference in lipid levels between the moderate and severe groups. The total lymphocytes were weakly positively associated with TC, LDL-c and apo...