Novel Risk Loci Associated With Genetic Risk for Bipolar Disorder Among Han Chinese Individuals

作者：Huijuan Li, Chen Zhang, Li Hui, Dongsheng Zhou, Yi Li, Chuyi Zhang, Chuang Wang, Lu Wang, Wenqiang Li, Yongfeng Yang, Na Qu, Jinsong Tang, Ying Hé, Jun Zhou, Zihao Yang, Xingxing Li, Jun Cai, Lu Yang, Jun Chen, Weixing Fan, Wei Tang, Wenxin Tang, Qiufang Jia, Weiqing Liu, Chuanjun Zhuo, Xueqin Song, Fang Liu, Yan Bai, Bao‐Liang Zhong, Shu-Fang Zhang, Jing Chen, Bin Xia, Luxian Lv, Zhongchun Liu, Shaohua Hu, Xiaoyan Li, Jie-wei Liu, Xin Cai, Yong‐Gang Yao, Yuyanan Zhang, Hao Yan, Suhua Chang, Jingping Zhao, Weihua Yue, Xiong‐Jian Luo, Xiaogang Chen, Xiao Xiao, Yiru Fang, Ming Li · 发表于：JAMA Psychiatry · 年份：2020 · DOI：10.1001/jamapsychiatry.2020.3738 · 被引用次数：78 · 研究领域：Genetic Associations and Epidemiology、Bipolar Disorder and Treatment、Schizophrenia research and treatment

Importance: The genetic basis of bipolar disorder (BD) in Han Chinese individuals is not fully understood. Objective: To explore the genetic basis of BD in the Han Chinese population. Design, Setting, and Participants: A genome-wide association study (GWAS), followed by independent replication, was conducted to identify BD risk loci in Han Chinese individuals. Individuals with BD were diagnosed based on DSM-IV criteria and had no history of schizophrenia, mental retardation, or substance dependence; individuals without any personal or family history of mental illnesses, including BD, were included as control participants. In total, discovery samples from 1822 patients and 4650 control participants passed quality control for the GWAS analysis. Replication analyses of samples from 958 patients and 2050 control participants were conducted. Summary statistics from the European Psychiatric Genomics Consortium 2 (PGC2) BD GWAS (20 352 cases and 31 358 controls) were used for the trans-ancestry genetic correlation analysis, polygenetic risk score analysis, and meta-analysis to compare BD genetic risk between Han Chinese and European individuals. The study was performed in February 2020. Main Outcomes and Measures: Single-nucleotide variations with P < 5.00 × 10-8 were considered to show genome-wide significance of statistical association. Results: The Han Chinese discovery GWAS sample included 1822 cases (mean [SD] age, 35.43 [14.12] years; 838 [46%] male) and 4650 controls (mean [S...