Dose Correlation of Danggui and Chuanxiong Drug Pairs in the Chinese Medicine Prescription Based on the Copula Function

作者：Xuan Zhao, Wei Lin, Jiawei Li, Yunhui Chen, Anamica Patel, Hai-Liang Zhao, Guoxin Han, Yiwen Hao, Chaomei Fu, Zejuan Huang, Mingyue Zheng, Peng Hu · 发表于：Evidence-based Complementary and Alternative Medicine · 年份：2020 · DOI：10.1155/2020/2372746 · 被引用次数：3 · 研究领域：Traditional Chinese Medicine Studies、Traditional Chinese Medicine Analysis、Andrographolide Research and Applications

Dosage is essential for studying the compatibility and effectiveness of traditional Chinese medicine. Danggui and Chuanxiong are widely used in traditional Chinese medicine for ailments and treatment of various disorders. 628 traditional Chinese medicine prescriptions containing Danggui and Chuanxiong were extracted from the self-built prescription database and screened for the three groups of prescriptions, i.e., irregular menstruation, sores, and stroke. We processed and tested the dosage of Danggui and Chuanxiong and selected the optimal copula function, Gumbel copula function, from the Archimedes function family and elliptical copula function family to establish the data model. To establish the presence of a correlation between the dose of Danggui and Chuanxiong, a graph of the joint distribution function of rank correlation coefficients, Kendall's rank correlation coefficient and Spearman's rank correlation coefficient, was used. Our results suggest that the model using the Gumbel copula function better reflects the correlation between the dose of Danggui and Chuanxiong. For irregular menstruation, sores, and strokes, Kendall's rank correlation coefficients were 0.6724, 0.5930, and 0.7757, respectively, and Spearman's correlation coefficients were 0.8536, 0.7812, and 0.9285, respectively. In all three prescription groups, the dose of Danggui and Chuanxiong was positively correlated, implying that, as the dosage of one drug increases, the dosage of the other increases as ...