Long non-coding RNA ZFAS1 promotes colorectal cancer tumorigenesis and development through DDX21-POLR1B regulatory axis

作者：Xiufang Wang, Zhikun Wu, Wenyan Qin, Tong Sun, Senxu Lu, Yalun Li, Yuanhe Wang, Xiaoyun Hu, Dong-ping Xu, Yutong Wu, Qiuchen Chen, Weifan Yao, Mingyan Liu, Minjie Wei, Huizhe Wu · 发表于：Aging · 年份：2020 · DOI：10.18632/aging.103875 · 被引用次数：33 · 研究领域：Cancer-related molecular mechanisms research

. Mechanistically, our research found that ZFAS1 could directly recruit DDX21 protein by harboring the specific motif (AAGA or CAGA). Finally, POLR1B was identified as the downstream target of DDX21 regulated by ZFAS1, which was also up-regulated in CRC cells and tissues and closely related to poor prognosis. The unrecognized ZFAS1/DDX21/POLR1B signaling regulation axis may provide new biomarkers and targets for CRC treatment and prognostic evaluation.