Association of Circulating Tumor DNA With Disease-Free Survival in Breast Cancer

作者：Carolyn M. Cullinane, Christina Fleming, Donal Peter O’Leary, Fara Hassan, Louise M. Kelly, Martin J. O’Sullivan, Mark Anthony Corrigan, Henry Paul Redmond · 发表于：JAMA Network Open · 年份：2020 · DOI：10.1001/jamanetworkopen.2020.26921 · 被引用次数：150 · 研究领域：Cancer Genomics and Diagnostics、Cancer Cells and Metastasis、Multiple and Secondary Primary Cancers

Importance: Fragmented DNA is continuously released into the circulation following apoptosis and necrosis of both cancerous and noncancerous cells; when it is released by cancer cells, it is specifically known as circulating tumor DNA (ctDNA). Previous studies have suggested that ctDNA can reflect tumor burden and guide potential therapeutic targets. Objective: To determine the association of ctDNA with breast cancer disease-free survival (DFS) and progression-free survival in early, locally advanced, and metastatic breast cancer. Data Sources: An electronic search was conducted using the Cochrane Library, ScienceDirect, PubMed, and Embase from July 30, 2019, to October 31, 2019; all languages were included. The following search terms were used: ctDNA OR circulating tumor DNA OR liquid biopsy AND breast cancer OR breast carcinoma OR breast tumor AND prognosis OR survival. All titles were screened, and the appropriate abstracts were reviewed. If any data were missing, the authors contacted the study authors for permission to access data and extrapolate hazard ratios (HRs). Study Selection: To be included in the analysis, the studies had to meet the following prespecified inclusion criteria: (1) a ctDNA blood sample was measured; (2) DFS, progression-free survival, or relapse-free survival was reported as an HR; and (3) the patient population only had breast cancer. Retrospective and prospective observational cohort studies were included. Data Extraction and Synthesis: Two auth...