The Treatment of Topical Drugs for Postherpetic Neuralgia: A Network Meta-Analysis

作者：Xi Liu, Liling Wei, Qiong Zeng, Kun Lin, Jia Zhang · 发表于：Pain Physician · 年份：2020 · DOI：10.36076/ppj.2020.23.541 · 被引用次数：19 · 研究领域：Pain Mechanisms and Treatments、Herpesvirus Infections and Treatments、Anesthesia and Pain Management

BACKGROUND: Postherpetic neuralgia (PHN) is a neuropathic pain that causes a reduction in patients' quality of life. There are many topical drugs for PHN, including topical lidocaine patch, topical application of capsaicin, and others. OBJECTIVES: This study aims to compare the efficacy and safety of topical drugs for PHN. STUDY DESIGN: Relevant studies were found by systemically searching for terms including "topical" and "Postherpetic neuralgia" in PubMed, Cochrane library, MEDLINE, and EMBASE databases (inception through June 12, 2019). The primary outcome was the percentage of change in the Numeric Rating Scale or the Visual Analog Scale scores from baseline. The secondary outcome was the number of adverse events. METHODS: The efficacy and safety of topical drugs for PHN was investigated by the pairwise meta-analysis and Bayesian network meta-analysis, applying Revman 5.3, the Stata 14.0 software, and GeMTC 0.14.3. RESULTS: Twelve studies met the inclusion criteria, and eligible studies were selected for the ultimate meta-analysis. Our meta-analysis displayed 6 topical drugs for PHN. Lidocaine, high-concentration capsaicin, and aspirin/diethyl ether (ADE) had a higher possibility of bringing pain relief than placebo. Among them, lidocaine had the highest possibility of being the most effective drug for PHN and had the statistical significances compared with diclofenac, high-concentration capsaicin, indomethacin, low-concentration capsaicin, and placebo, and lidocaine was ...