Organizing pneumonia of COVID-19: Time-dependent evolution and outcome in CT findings

作者：Yan Wang, Chao Jin, Carol C. Wu, Huifang Zhao, Ting Liang, Zhe Liu, Zhijie Jian, Runqing Li, Zekun Wang, Fen Li, Jie Zhou, Shubo Cai, Yang Liu, Hao Li, Yukun Liang, Cong Tian, Jian Yang · 发表于：PLoS ONE · 年份：2020 · DOI：10.1371/journal.pone.0240347 · 被引用次数：59 · 研究领域：COVID-19 Clinical Research Studies、Long-Term Effects of COVID-19、Sarcoidosis and Beryllium Toxicity Research

BACKGROUND: As a pandemic, a most-common pattern resembled organizing pneumonia (OP) has been identified by CT findings in novel coronavirus disease (COVID-19). We aimed to delineate the evolution of CT findings and outcome in OP of COVID-19. MATERIALS AND METHODS: 106 COVID-19 patients with OP based on CT findings were retrospectively included and categorized into non-severe (mild/common) and severe (severe/critical) groups. CT features including lobar distribution, presence of ground glass opacities (GGO), consolidation, linear opacities and total severity CT score were evaluated at three time intervals from symptom-onset to CT scan (day 0-7, day 8-14, day > 14). Discharge or adverse outcome (admission to ICU or death), and pulmonary sequelae (complete absorption or lesion residuals) on CT after discharge were analyzed based on the CT features at different time interval. RESULTS: 79 (74.5%) patients were non-severe and 103 (97.2%) were discharged at median day 25 (range, day 8-50) after symptom-onset. Of 67 patients with revisit CT at 2-4 weeks after discharge, 20 (29.9%) had complete absorption of lesions at median day 38 (range, day 30-53) after symptom-onset. Significant differences between complete absorption and residuals groups were found in percentages of consolidation (1.5% vs. 13.8%, P = 0.010), number of involved lobe > 3 (40.0% vs. 72.5%, P = 0.030), CT score > 4 (20.0% vs. 65.0%, P = 0.010) at day 8-14. CONCLUSION: Most OP cases had good prognosis. Approximately...