Linezolid Induced Lactic Acidosis: The Side Effect, Clinician Should Be Aware of

作者：Savannah Nightingale, Charlotte Austin, Khushboo K Agarwal, Mayurkumar Patel, Mohammad Hossain · 发表于：Cureus · 年份：2020 · DOI：10.7759/cureus.11514 · 被引用次数：5 · 研究领域：Antimicrobial Resistance in Staphylococcus、Antibiotics Pharmacokinetics and Efficacy、Bacterial Identification and Susceptibility Testing

Linezolid is a synthetic antibiotic that functions through the inhibition of bacterial protein synthesis by binding to ribosomal ribonucleic acid (rRNA). Deliverable in both intravenous and oral form, with a low level of resistance amongst Methicillin-resistant Staphylococcus aureus (MRSA) strains, it is recommended for a wide range of gram-positive infections. We present a case of a male patient who underwent endovascular abdominal aortic aneurysm repair complicated by abdominal sepsis due to bowel ischemia; several days after linezolid therapy was initiated, he presented with signs of lactic acidosis. After excluding other sources such as metabolic, hypoxia, or organ damage, the resulting lactic acidosis was determined to be a side effect of linezolid.