Rhodium‐Catalyzed Synthesis of Chiral Monohydrosilanes by Intramolecular C−H Functionalization of Dihydrosilanes

作者：Wenpeng Ma, Li‐Chuan Liu, Kun An, Tao He, Wei He · 发表于：Angewandte Chemie International Edition · 年份：2020 · DOI：10.1002/anie.202013041 · 被引用次数：98 · 研究领域：Organoboron and organosilicon chemistry、Catalytic C–H Functionalization Methods、Catalytic Cross-Coupling Reactions

Abstract The preparation of chiral monohydrosilanes remains a rarely achieved goal. To this end a Rh‐catalyzed desymmetrization of dihydrosilanes by way of intramolecular C(sp 2 )−H functionalization under simple and mild conditions has now been developed. This method provides easy access to a broad range of chiral monohydrosilanes in good yields with excellent enantioselectivities (up to >99 % ee ). The resulting monohydrosilanes constitute a good platform to access stereogenic silicon compounds, as well as useful compounds to probe silicon stereochemistry.