The 14-3-3σ protein promotes HCC anoikis resistance by inhibiting EGFR degradation and thereby activating the EGFR-dependent ERK1/2 signaling pathway

作者：Jia Song, Yachong Liu, Furong Liu, Lu Zhang, Ganxun Li, Chaoyi Yuan, Chengpeng Yu, Xun Lu, Qiumeng Liu, Xiaoping Chen, Huifang Liang, Zeyang Ding, Bixiang Zhang · 发表于：Theranostics · 年份：2020 · DOI：10.7150/thno.51646 · 被引用次数：96 · 研究领域：14-3-3 protein interactions、Microbial Natural Products and Biosynthesis、ATP Synthase and ATPases Research

Our results indicate that 14-3-3σ plays a pivotal role in the anoikis resistance and metastasis of HCC cells, presumably by inhibiting EGFR degradation and regulating the activation of the EGFR-dependent ERK1/2 pathway. To our best knowledge, this is the first report of the role of 14-3-3σ in the anoikis resistance of HCC cells, offering new research directions for the treatment of metastatic cancer by targeting 14-3-3σ.