Dietary simple sugars alter microbial ecology in the gut and promote colitis in mice

作者：Shahanshah Khan, Sumyya Waliullah, Victoria Godfrey, Md Abdul Wadud Khan, Rajalaksmy A. Ramachandran, Brandi L. Cantarel, Cassie L. Behrendt, Lan Peng, Lora V. Hooper, Hasan Zaki · 发表于：Science Translational Medicine · 年份：2020 · DOI：10.1126/scitranslmed.aay6218 · 被引用次数：330 · 研究领域：Gut microbiota and health、Probiotics and Fermented Foods、Helicobacter pylori-related gastroenterology studies

mice. Sugar-induced exacerbation of colitis was not observed when mice were treated with antibiotics or maintained in a germ-free environment, suggesting that altered microbiota played a critical role in sugar-induced colitis pathogenesis. Furthermore, germ-free mice colonized with microbiota from sugar-treated mice showed increased colitis susceptibility. Together, these data suggest that intake of simple sugars predisposes to colitis and enhances its pathogenesis via modulation of gut microbiota in mice.