Ruthenium-Catalyzed C(sp2)–H Bond Bisallylation with Imidazopyridines as Directing Groups

作者：Shuang Liu, Hui Jiang, Wannian Liu, Xinju Zhu, Xin‐Qi Hao, Mao‐Ping Song · 发表于：The Journal of Organic Chemistry · 年份：2020 · DOI：10.1021/acs.joc.0c02029 · 被引用次数：28 · 研究领域：Catalytic C–H Functionalization Methods、Synthesis and Catalytic Reactions、Cyclopropane Reaction Mechanisms

A Ru(II)-catalyzed bisallylation of imidazopyridines with vinylcyclopropanes or vinyl cyclic carbonate has been successfully realized. Notably, pharmacophore imidazopyridine was utilized as an intrinsic directing group, which gave access to value-added bisallylated products in high yields via double tandem C-H and C-C/C-O activation. The current methodology was featured with broad substrate scope, good functional group compatibility, and operational simplicity.