Association between physiological responses after exercise at low altitude and acute mountain sickness upon ascent is sex-dependent

作者：Yang Shen, Yuanqi Yang, Chuan Liu, Jie Yang, Jihang Zhang, Jun Jin, Tan H, Fangzhengyuan Yuan, Jingbin Ke, Chunyan He, Lai-Ping Zhang, Chen Zhang, Jie Yu, Lan Huang · 发表于：Military Medical Research · 年份：2020 · DOI：10.1186/s40779-020-00283-3 · 被引用次数：27 · 研究领域：High Altitude and Hypoxia、Travel-related health issues、Neuroscience of respiration and sleep

Abstract Background Acute mountain sickness (AMS) is the mildest form of acute altitude illnesses, and consists of non-specific symptoms when unacclimatized persons ascend to elevation of ≥2500 m. Risk factors of AMS include: the altitude, individual susceptibility, ascending rate and degree of pre-acclimatization. In the current study, we examined whether physiological response at low altitude could predict the development of AMS. Methods A total of 111 healthy adult healthy volunteers participated in this trial; and 99 (67 men and 32 women) completed the entire study protocol. Subjects were asked to complete a 9-min exercise program using a mechanically braked bicycle ergometer at low altitude (500 m). Heart rate, blood pressure (BP) and pulse oxygen saturation (SpO 2 ) were recorded prior to and during the last minute of exercise. The ascent from 500 m to 4100 m was completed in 2 days. AMS was defined as ≥3 points in a 4-item Lake Louise Score, with at least one point from headache wat 6–8 h after the ascent. Results Among the 99 assessable subjects, 47 (23 men and 24 women) developed AMS at 4100 m. In comparison to the subjects without AMS, those who developed AMS had lower proportion of men (48.9% vs. 84.6%, P < 0.001), height (168.4 ± 5.9 vs. 171.3 ± 6.1 cm, P = 0.019), weight (62.0 ± 10.0 vs. 66.7 ± 8.6 kg, P = 0.014) and proportion of smokers (23.4% vs. 51.9%, P = 0.004). Multivariate regression analysis revealed the following independent risks for AMS: female sex...