P-selectin glycoprotein ligand 1 deficiency prevents development of acute pancreatitis by attenuating leukocyte infiltration

作者：Xu Zhang, Ming Zhu, Xiaoliang Jiang, Xing Liu, Xue Liu, Pan Liu, Xianxian Wu, Zhiwei Yang, Tao Qin · 发表于：World Journal of Gastroenterology · 年份：2020 · DOI：10.3748/wjg.v26.i41.6361 · 被引用次数：14 · 研究领域：Pancreatitis Pathology and Treatment、IgG4-Related and Inflammatory Diseases、Cell Adhesion Molecules Research

BACKGROUND: Acute pancreatitis (AP) is rapid-onset pancreatic inflammation that causes local and systemic inflammatory response syndrome (SIRS) with high morbidity and mortality, but no approved therapies are currently available. P-selectin glycoprotein ligand 1 (PSGL-1) is a transmembrane glycoprotein to initiate inflammatory responses. We hypothesized that PSGL-1 may be involved in the development of AP and would be a new target for the treatment of AP. AIM: To investigate the role and mechanism of PSGL-1 in the development of AP. METHODS: ) mice. Leukocyte-endothelial cell adhesion was measured in a peripheral blood mononuclear cell (PBMC)-endothelial cell coculture system. RESULTS: IL-6 but not IL-1beta. CONCLUSION: IL-6 stimulation and may become a potential therapeutic target for treating AP.