Bone marrow dendritic cell aggregates associate with systemic immune dysregulation in chronic myelomonocytic leukemia

作者：Abhishek Avinash Mangaonkar, Kaaren K. Reichard, Moritz Binder, Giacomo Coltro, Terra L. Lasho, Ryan Michael Carr, April Chiu, Vivian C. Negron, Mehrdad Hefazi, Theodora Anagnostou, Michael Timm, James W. Hiebert, Jose Caetano Villasboas, Wilson I. Gonsalves, Naseema Gangat, Mithun Vinod Shah, Hassan B. Alkhateeb, Aref Al‐Kali, Michelle Ann Elliott, Kebede H. Begna, Alexandra P. Wolanskyj, Mark Robert Litzow, William J. Hogan, Stephen Maxted Ansell, Animesh Dev Pardanani, Ayalew Tefferi, Mrinal M. Patnaik · 发表于：Blood Advances · 年份：2020 · DOI：10.1182/bloodadvances.2020002415 · 被引用次数：30 · 研究领域：Immune Cell Function and Interaction、Acute Myeloid Leukemia Research、Immune cells in cancer

Key Points Systemic immune microenvironment signatures in CMML indicate an altered T- and natural killer cell balance. CMML bone marrow dendritic cell aggregates associate with disease progression and systemic regulatory T-cell phenotypic switch.