Flavonoids in myocardial ischemia-reperfusion injury: Therapeutic effects and mechanisms

作者：Jun-ying Jia, Erhuan Zang, Lijuan Lv, Qinyu Li, Chunhua Zhang, Ying Xia, Lei Zhang, Lian-sheng Dang, Minhui Li · 发表于：Chinese Herbal Medicines · 年份：2020 · DOI：10.1016/j.chmed.2020.09.002 · 被引用次数：50 · 研究领域：Cardiac Ischemia and Reperfusion、Traditional Chinese Medicine Analysis、Sirtuins and Resveratrol in Medicine

Ischemic heart diseases are one of the major causes of death worldwide. Effective restoration of blood flow can significantly improve patients' quality of life and reduce mortality. However, reperfusion injury cannot be ignored. Flavonoids possess well-established antioxidant properties; They also have other benefits that may be relevant for ameliorating myocardial ischemia-reperfusion injury (MIRI). In this review, we focus on flavonoids with cardiovascular-protection function and emphasize their pharmacological effects. The main mechanisms of flavonoid pharmacological activities against MIRI involve the following aspects: a) antioxidant, b) anti-inflammatory, c) anti-platelet aggregation, d) anti-apoptosis, and e) myocardial-function regulation activities. We also summarized the effectiveness of flavonoids for MIRI.