Effects of the SNAP25 on Integration Ability of Brain Functions in Children With ADHD

作者：Yue Yang, Gang Peng, Hongwu Zeng, Diangang Fang, Linlin Zhang, Shoujun Xu, Binrang Yang · 发表于：Journal of Attention Disorders · 年份：2020 · DOI：10.1177/1087054720964561 · 被引用次数：7 · 研究领域：Attention Deficit Hyperactivity Disorder、Neural and Behavioral Psychology Studies、Functional Brain Connectivity Studies

OBJECTIVE: on the integration ability of intrinsic brain functions in children with ADHD, and whether the integration ability was associated with working memory (WM). METHODS: A sliding time window method was used to calculate the spatial and temporal concordance among five rs-fMRI regional indices in 55 children with ADHD and 20 healthy controls. RESULTS: exhibited significant interaction effects with ADHD diagnosis on the voxel-wise concordance in the right posterior central gyrus, fusiform gyrus and lingual gyrus. Specifically, for children with ADHD, G-carriers showed increased voxel-wise concordance in comparison to TT homozygotes in the right precentral gyrus, superior frontal gyrus, postcentral gyrus, and middle frontal gyrus. The voxel-wise concordance was also found to be related to WM. CONCLUSION: Our findings provided a new insight into the neural mechanisms of the brain function of ADHD children.