Acute encephalopathy with biphasic seizures and late reduced diffusion

作者：Yanli Ma, Kaili Xu, Guohong Chen, Li Wang, Yuan Wang, Zhipeng Jin · 发表于：Medicine · 年份：2020 · DOI：10.1097/md.0000000000022940 · 被引用次数：7 · 研究领域：Infectious Encephalopathies and Encephalitis、Long-Term Effects of COVID-19、Neurological and metabolic disorders

RATIONALE: Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) has been reported almost exclusively in the Japanese population. PATIENT CONCERNS: A 17-month-old male patient presented with fever and seizures, and subsequently fell into a coma. On the second day, he recovered consciousness. On the fourth day, he developed complex partial seizures and fell into a coma again. On day 10, the fever and seizures subsided. Head computed tomography on the first day showed no abnormalities. Brain diffusion-weighted images on the fourth day revealed reduced diffusion in the bilateral subcortical white matter. DIAGNOSIS: A diagnosis of AESD was made. INTERVENTIONS: The patient was treated with corticosteroids and intravenous immunoglobulin. OUTCOMES: At the 4-month follow-up, the patient was able to walk independently, and the epileptic seizures were well controlled. LESSONS: AESD is a rare entity, and treatment with corticosteroids and intravenous immunoglobulin can lead to a favorable prognosis. Clinicians should be aware of this condition, and clinicoradiological features can suggest the diagnosis.