A high-stringency blueprint of the human proteome

作者：Subash Adhikari, Edouard Collins Nice, Eric W. Deutsch, Lydie Lane, Gilbert S. Omenn, Stephen R. Pennington, Young‐Ki Paik, Christopher M. Overall, Fernando José Corrales, Ileana M. Cristea, Jennifer E. Van Eyk, Mathias Uhlén, Cecilia Lindskog, Daniel W. Chan, Amos Bairoch, James C. Waddington, Joshua Justice, Joshua LaBaer, Henry Rodriguez, Fuchu He, Markus Kostrzewa, Peipei Ping, Rebekah L. Gundry, Peter Stewart, Sanjeeva Srivastava, Sudhir Srivastava, Fábio César Sousa Nogueira, Gilberto B. Domont, Yves Vandenbrouck, Maggie P. Y. Lam, Sara A. Wennersten, Juan Antonio Vizcaíno, Marc Ronald Wilkins, Jochen M. Schwenk, Emma K. Lundberg, Nuno Bandeira, György Marko‐Varga, Susan T. Weintraub, Charles P. Pineau, Ulrike Kusebauch, Robert L. Moritz, Seong Beom Ahn, Magnus Palmblad, Michael Snyder, Ruedi Aebersold, Mark S. Baker · 发表于：Nature Communications · 年份：2020 · DOI：10.1038/s41467-020-19045-9 · 被引用次数：220 · 研究领域：Advanced Proteomics Techniques and Applications、vaccines and immunoinformatics approaches、Genetics, Bioinformatics, and Biomedical Research

The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP's tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.