Correlation between Mitochondrial Dysfunction, Cardiovascular Diseases, and Traditional Chinese Medicine

作者：Li Zhu, Zhigang Chen, Keli Han, Yilin Zhao, Yan Li, Dongxu Li, Xiulong Wang, Xuefang Li, Siyu Sun, Fei Lin, Guoan Zhao · 发表于：Evidence-based Complementary and Alternative Medicine · 年份：2020 · DOI：10.1155/2020/2902136 · 被引用次数：15 · 研究领域：Traditional Chinese Medicine Studies、Mitochondrial Function and Pathology、Metabolomics and Mass Spectrometry Studies

Cardiovascular disease (CVD) is the number one threat that seriously endangers human health. However, the mechanism of their occurrence is not completely clear. Increasing studies showed that mitochondrial dysfunction is closely related to CVD. Possible causes of mitochondrial dysfunction include oxidative stress, Ca 2+ disorder, mitochondrial DNA mutations, and reduction of mitochondrial biosynthesis, all of which are closely related to the development of CVD. At present, traditional Chinese medicine (TCM) is widely used in the treatment of CVD. TCM has the therapeutic characteristics of multitargets and multipathways. Studies have shown that TCM can treat CVD by protecting mitochondrial function. Via systematic literature review, the results show that the specific mechanisms include antioxidant stress, regulation of calcium homeostasis, antiapoptosis, and regulation of mitochondrial biosynthesis. This article describes the relationship between mitochondrial dysfunction and CVD, summarizes the TCM commonly used for the treatment of CVD in recent years, and focuses on the regulatory effect of TCM on mitochondrial function.