Synthesis of graphene quantum dots and their applications in drug delivery

作者：Changhong Zhao, Xuebin Song, Ya Liu, Yifeng Fu, Lilei Ye, Nan Wang, Fan Wang, Lu Li, Mohsen Mohammadniaei, Ming Zhang, Qiqing Zhang, Johan Liu · 发表于：Journal of Nanobiotechnology · 年份：2020 · DOI：10.1186/s12951-020-00698-z · 被引用次数：331 · 研究领域：Carbon and Quantum Dots Applications、Graphene and Nanomaterials Applications、Nanocluster Synthesis and Applications

This review focuses on the recent advances in the synthesis of graphene quantum dots (GQDs) and their applications in drug delivery. To give a brief understanding about the preparation of GQDs, recent advances in methods of GQDs synthesis are first presented. Afterwards, various drug delivery-release modes of GQDs-based drug delivery systems such as EPR-pH delivery-release mode, ligand-pH delivery-release mode, EPR-Photothermal delivery-Release mode, and Core/Shell-photothermal/magnetic thermal delivery-release mode are reviewed. Finally, the current challenges and the prospective application of GQDs in drug delivery are discussed.