Gold Nanoclusters for NIR‐II Fluorescence Imaging of Bones

作者：Deling Li, Qiang Liu, Qingrong Qi, Hui Shi, En‐Chi Hsu, Weiyu Chen, Wen‐Li Yuan, Yifan Wu, Sien Lin, Yitian Zeng, Zunyu Xiao, Lingyun Xu, Yanrong Zhang, Tanya Ivanova Stoyanova, Wang Xiao Jia, Zhen Xiang Cheng · 发表于：Small · 年份：2020 · DOI：10.1002/smll.202003851 · 被引用次数：166 · 研究领域：Nanocluster Synthesis and Applications、Advanced Nanomaterials in Catalysis、Nanoplatforms for cancer theranostics

Abstract Fluorescence imaging in the second near‐infrared window (NIR‐II, 1000–1700 nm) holds great promise for deep tissue visualization. Development of novel clinical translatable NIR‐II probes is crucial for realizing the medical applications of NIR‐II fluorescence imaging. Herein, the glutathione‐capped gold nanoclusters (AuNCs, specifically Au25(SG)18) demonstrate highly efficient binding capability to hydroxyapatite in vitro for the first time. Further in vivo NIR‐II fluorescence imaging of AuNCs indicate that they accumulate in bone tissues with high contrast and signal‐background ratio. AuNCs are also mainly and quickly excreted from body through renal system, showing excellent ribs and thoracic vertebra imaging because of no background signal in liver and spleen. The deep tissue penetration capability and high resolution of AuNCs in NIR‐II imaging render their great potential for fluorescence‐guided surgery like spinal pedicle screw implantation. Overall, AuNCs are highly promising and clinical translatable NIR‐II imaging probe for visualizing bone and bone related abnormalities.