Different T-cell subsets in glioblastoma multiforme and targeted immunotherapy

作者：Hongsheng Wang, Huangao Zhou, Jianing Xu, Yunpeng Lu, Xiaoyun Ji, Yizheng Yao, Chao Hou, Jun Zhang, Xiaochun Zhang, Shun Yao, Yinqiu Wu, Jie Wan · 发表于：Cancer Letters · 年份：2020 · DOI：10.1016/j.canlet.2020.09.028 · 被引用次数：90 · 研究领域：Glioma Diagnosis and Treatment、Immunotherapy and Immune Responses、CAR-T cell therapy research

Glioblastoma multiforme (GBM) is a brain tumor with a high mortality rate. Surgical resection combined with radiotherapy and chemotherapy is the standard treatment for GBM patients, but the 5-year survival rate of patients despite this treatment is low. Immunotherapy has attracted increasing attention in recent years. As the pioneer and the main effector cells of immunotherapy, T cells play a key role in tumor immunotherapy. However, the T cells in GBM microenvironment are inhibited by the highly immunosuppressive environment of GBM, posing huge challenges to T cell-based GBM immunotherapy. This review summarizes the effects of the GBM microenvironment on the infiltration and function of different T-cell subsets and the possible strategies to overcome immunosuppression, and thus enhance the effectiveness of GBM immunotherapy.