<p>Metabolic Syndrome and Incident Asthma in Chinese Adults: An Open Cohort Study</p>

作者：Haixia Wang, Chenxiao Bai, Mo Yi, Yuanmin Jia, Yizhang Li, Di Jiang, Ou Chen · 发表于：Diabetes Metabolic Syndrome and Obesity · 年份：2020 · DOI：10.2147/dmso.s274159 · 被引用次数：12 · 研究领域：Asthma and respiratory diseases、Adipokines, Inflammation, and Metabolic Diseases、Health, Environment, Cognitive Aging

Background: Although metabolic syndrome is awell-known risk factor for many non-communicable diseases, its contribution to asthma remains controversial. Objective: The aim of this study was to explore the associations of metabolic syndrome and its components with incident asthma in Chinese adults. Methods: We conducted an open cohort study of participants who were asthma-free at baseline (n=42,304) in the Shandong multi-center health check-up longitudinal study from 2004 to 2015. Participants aged ≥ 20 years and had regular physical examination (once ayear) more than three times during follow-up. Results: Ninety subjects (38 women and 52 men) developed incident asthma over 12 years of follow-up. Our study suggested that metabolic syndrome itself was not significantly associated with incident asthma in either women or men ( P > 0.050). Interestingly, we found that overweight and/or obesity was arisk factor for incident asthma among women but not men in the Cox proportional hazards model after adjusting covariates (adjusted incidence rate ratio (IRR)= 2.940, 95% confidence interval (CI): 1.467– 5.894, P=0.002). The result was consistent with the Poisson regression model (hazard ratio (HR)= 2.241, 95% CI: 1.135– 4.988, P=0.026). After stratifying according to overweight and/or obesity, we found that female subjects with overweight and obesity were associated with the occurrence of incident asthma ( P < 0.050). However, we did not find this result among men. Conclusion: Metabolic...