PTEN status determines chemosensitivity to proteasome inhibition in cholangiocarcinoma

作者：Tianyi Jiang, Yufei Pan, Zhenghua Wan, Yun‐Kai Lin, Bin Zhu, Zhen-Gang Yuan, Yunhan Ma, Yuanyuan Shi, Tian-Mei Zeng, Liwei Dong, Yexiong Tan, Hongyang Wang · 发表于：Science Translational Medicine · 年份：2020 · DOI：10.1126/scitranslmed.aay0152 · 被引用次数：66 · 研究领域：Cholangiocarcinoma and Gallbladder Cancer Studies、RNA modifications and cancer、Peptidase Inhibition and Analysis

BACH1 and MAFF are transcriptional regulators that recognize the antioxidant response element, which is present in genes encoding proteasome subunits. PTEN induced the accumulation and nuclear translocation of these proteins, which directly repressed the transcription of genes encoding proteasome subunits. We revealed that the PTEN-proteasome axis is a potential target for therapy in PTEN-deficient CCA and other PTEN-deficient cancers.