Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients

作者：Carl A. Pierce, Paula Preston‐Hurlburt, Yile Dai, Clare Burn Aschner, Natalia Cheshenko, Benjamin T Galen, S. Garforth, Natalia G. Herrera, Rohit K. Jangra, Nicholas C. Morano, Erika P. Orner, Sharlene Sy, Kartik Chandran, James D Dziura, Steven C. Almo, Aaron M. Ring, Marla J. Keller, Kevan C. Herold, Betsy C. Herold · 发表于：Science Translational Medicine · 年份：2020 · DOI：10.1126/scitranslmed.abd5487 · 被引用次数：394 · 研究领域：COVID-19 Clinical Research Studies、SARS-CoV-2 and COVID-19 Research、Long-Term Effects of COVID-19

T cells. Moreover, serum neutralizing antibody titers and antibody-dependent cellular phagocytosis were higher in adults compared to pediatric patients with COVID-19. The neutralizing antibody titer correlated positively with age and negatively with IL-17A and IFN-γ serum concentrations. There were no differences in anti-spike protein antibody titers to other human coronaviruses. Together, these findings demonstrate that the poor outcome in hospitalized adults with COVID-19 compared to children may not be attributable to a failure to generate adaptive immune responses.