Ultralong purely organic aqueous phosphorescence supramolecular polymer for targeted tumor cell imaging

作者：Wei‐Lei Zhou, Yong Chen, Qilin Yu, Haoyang Zhang, Zhixue Liu, Xianyin Dai, Jingjing Li, Yu Liu · 发表于：Nature Communications · 年份：2020 · DOI：10.1038/s41467-020-18520-7 · 被引用次数：302 · 研究领域：Luminescence and Fluorescent Materials、Molecular Sensors and Ion Detection、Supramolecular Chemistry and Complexes

Purely organic room-temperature phosphorescence has attracted attention for bioimaging but can be quenched in aqueous systems. Here we report a water-soluble ultralong organic room-temperature phosphorescent supramolecular polymer by combining cucurbit[n]uril (CB[7], CB[8]) and hyaluronic acid (HA) as a tumor-targeting ligand conjugated to a 4-(4-bromophenyl)pyridin-1-ium bromide (BrBP) phosphor. The result shows that CB[7] mediated pseudorotaxane polymer CB[7]/HA-BrBP changes from small spherical aggregates to a linear array, whereas complexation with CB[8] results in biaxial pseudorotaxane polymer CB[8]/HA-BrBP which transforms to relatively large aggregates. Owing to the more stable 1:2 inclusion complex between CB[8] and BrBP and the multiple hydrogen bonds, this supramolecular polymer has ultralong purely organic RTP lifetime in water up to 4.33 ms with a quantum yield of 7.58%. Benefiting from the targeting property of HA, this supramolecular polymer is successfully applied for cancer cell targeted phosphorescence imaging of mitochondria.