Short- and potential long-term adverse health outcomes of COVID-19: a rapid review

作者：Miriam T Y Leung, Adrienne Y L Chan, Esther W. Chan, Vivien Kin Yi Chan, Celine Sze Ling Chui, Benjamin John Cowling, Le Gao, M. Q. Ge, Ivan Fan‐Ngai Hung, M. S. M. Ip, Patrick Ip, Kelvin Kar Wing Lau, Chak Sing Lau, Llh Lau, Alex Wing Kwan Leung, Xue Li, Hao Luo, Kenneth K. C. Man, V Ng, Chung‐Wah Siu, Eric Yuk Fai Wan, Yun Kwok Wing, Christina Sze Man Wong, Kirstie H. T. W. Wong, Ian Chi Kei Wong · 发表于：Emerging Microbes & Infections · 年份：2020 · DOI：10.1080/22221751.2020.1825914 · 被引用次数：240 · 研究领域：Long-Term Effects of COVID-19、COVID-19 Clinical Research Studies、SARS-CoV-2 and COVID-19 Research

The coronavirus disease 2019 (COVID-19) pandemic has resulted in millions of patients infected worldwide and indirectly affecting even more individuals through disruption of daily living. Long-term adverse outcomes have been reported with similar diseases from other coronaviruses, namely Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS). Emerging evidence suggests that COVID-19 adversely affects different systems in the human body. This review summarizes the current evidence on the short-term adverse health outcomes and assesses the risk of potential long-term adverse outcomes of COVID-19. Major adverse outcomes were found to affect different body systems: immune system (including but not limited to Guillain-Barré syndrome and paediatric inflammatory multisystem syndrome), respiratory system (lung fibrosis and pulmonary thromboembolism), cardiovascular system (cardiomyopathy and coagulopathy), neurological system (sensory dysfunction and stroke), as well as cutaneous and gastrointestinal manifestations, impaired hepatic and renal function. Mental health in patients with COVID-19 was also found to be adversely affected. The burden of caring for COVID-19 survivors is likely to be huge. Therefore, it is important for policy makers to develop comprehensive strategies in providing resources and capacity in the healthcare system. Future epidemiological studies are needed to further investigate the long-term impact on COVID-19 survivors.