Ultrathin and Robust Hydrogel Coatings on Cardiovascular Medical Devices to Mitigate Thromboembolic and Infectious Complications

作者：German Alberto Parada, Yan Yu, William B. Riley, Sarah Lojovich, Diane M. Tshikudi, Qing Ling, Yefang Zhang, Jiaxin Wang, Lei Ling, Yueying Yang, Seemantini K. Nadkarni, Christoph S. Nabzdyk, Xuanhe Zhao · 发表于：Advanced Healthcare Materials · 年份：2020 · DOI：10.1002/adhm.202001116 · 被引用次数：120 · 研究领域：Electrospun Nanofibers in Biomedical Applications、Polymer Surface Interaction Studies、Hemostasis and retained surgical items

Thromboembolic and infectious complications stemming from the use of cardiovascular medical devices are still common and result in significant morbidity and mortality. There is no strategy to date that effectively addresses both challenges at the same time. Various surface modification strategies (e.g., silver, heparin, and liquid-impregnated surfaces) are proposed yet each has several limitations and shortcomings. Here, it is shown that the incorporation of an ultrathin and mechanically robust hydrogel layer reduces bacterial adhesion to medical-grade tubing by 95%. It is additionally demonstrated, through a combination of in vitro and in vivo tests, that the hydrogel layer significantly reduces the formation and adhesion of blood clots to the tubing without affecting the blood's intrinsic clotting ability. The adhesion of clots to the tubing walls is reduced by over 90% (in vitro model), which results in an ≈60% increase in the device occlusion time (time before closure due to clot formation) in an in vivo porcine model. The advantageous properties of this passive coating make it a promising surface material candidate for medical devices interfacing with blood.