Copper-catalyzed oxidative benzylic C(sp 3 )–H amination: direct synthesis of benzylic carbamates

作者：Shuai Liu, Raphaël Achou, Coline Boulanger, Govind Goroba Pawar, N. N. Bhuvan Kumar, Jonathan Lusseau, Frédéric Robert, Yannick Landais · 发表于：Chemical Communications · 年份：2020 · DOI：10.1039/d0cc05226d · 被引用次数：35 · 研究领域：Synthesis and Catalytic Reactions、Catalytic C–H Functionalization Methods、Sulfur-Based Synthesis Techniques

A new efficient strategy to access benzylic carbamates through C-H activation is reported. The use of a catalytic amount of a Cu(i)/diimine ligand in combination with NFSI ((PhSO2)2NF) or F-TEDA-PF6 as oxidants and H2NCO2R as an amine source directly leads to the C-N bond formation at the benzylic position. The mild reaction conditions and the broad substrate scope make this transformation a useful method for the late-stage incorporation of a ubiquitous carbamate fragment onto hydrocarbons.