The Role of Chondroitin Sulfate Proteoglycans in Nervous System Development

作者：Caitlin P. Mencio, Rowan K. Hussein, Panpan Yu, Herbert M. Geller · 发表于：Journal of Histochemistry & Cytochemistry · 年份：2020 · DOI：10.1369/0022155420959147 · 被引用次数：71 · 研究领域：Proteoglycans and glycosaminoglycans research、Glycosylation and Glycoproteins Research、Connective tissue disorders research

The orderly development of the nervous system is characterized by phases of cell proliferation and differentiation, neural migration, axonal outgrowth and synapse formation, and stabilization. Each of these processes is a result of the modulation of genetic programs by extracellular cues. In particular, chondroitin sulfate proteoglycans (CSPGs) have been found to be involved in almost every aspect of this well-orchestrated yet delicate process. The evidence of their involvement is complex, often contradictory, and lacking in mechanistic clarity; however, it remains obvious that CSPGs are key cogs in building a functional brain. This review focuses on current knowledge of the role of CSPGs in each of the major stages of neural development with emphasis on areas requiring further investigation.