Universal screening for SARS-CoV-2 infection: a rapid review

作者：Meera Sushila Viswanathan, Leila C. Kahwati, Beate Jahn, Kayla Giger, Andreea Iulia Dobrescu, Christine Hill, Irma Klerings, Jana Meixner, Emma Persad, Birgit Teufer, Gerald Gartlehner · 发表于：Cochrane Database of Systematic Reviews · 年份：2020 · DOI：10.1002/14651858.cd013718 · 被引用次数：84 · 研究领域：SARS-CoV-2 detection and testing、COVID-19 epidemiological studies、SARS-CoV-2 and COVID-19 Research

BACKGROUND: Coronavirus disease 2019 (COVID-19) is caused by the novel betacoronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Most people infected with SARS-CoV-2 have mild disease with unspecific symptoms, but about 5% become critically ill with respiratory failure, septic shock and multiple organ failure. An unknown proportion of infected individuals never experience COVID-19 symptoms although they are infectious, that is, they remain asymptomatic. Those who develop the disease, go through a presymptomatic period during which they are infectious. Universal screening for SARS-CoV-2 infections to detect individuals who are infected before they present clinically, could therefore be an important measure to contain the spread of the disease. OBJECTIVES: We conducted a rapid review to assess (1) the effectiveness of universal screening for SARS-CoV-2 infection compared with no screening and (2) the accuracy of universal screening in people who have not presented to clinical care for symptoms of COVID-19. SEARCH METHODS: An information specialist searched Ovid MEDLINE and the Centers for Disease Control (CDC) COVID-19 Research Articles Downloadable Database up to 26 May 2020. We searched Embase.com, the CENTRAL, and the Cochrane Covid-19 Study Register on 14 April 2020. We searched LitCovid to 4 April 2020. The World Health Organization (WHO) provided records from daily searches in Chinese databases and in PubMed up to 15 April 2020. We also searched three...