Heterogenous Internalization of Nanoparticles at Ultra-Trace Concentration in Environmental Individual Unicellular Organisms Unveiled by Single-Cell Mass Cytometry

作者：Qi Wu, Jianbo Shi, Xiaomeng Ji, Tian Xia, Li Zeng, Gengtan Li, Yuanyuan Wang, Jie Gao, Linlin Yao, Junjie Ma, Xiaolei Liu, Nian Liu, Ligang Hu, Bin He, Yong Liang, Guangbo Qu, Guibin Jiang · 发表于：ACS Nano · 年份：2020 · DOI：10.1021/acsnano.0c03587 · 被引用次数：35 · 研究领域：Nanoparticles: synthesis and applications、3D Printing in Biomedical Research、Single-cell and spatial transcriptomics

cells could concentrate AuNPs, indicating a real environmental concern even when water was contaminated by only trace level of NPs. This method represents a promising tool for simultaneous determination of physiological status of cells together with the intracellular level of heavy metal or metallic NPs in study of biological effects.