Activity‐Based NIR Enzyme Fluorescent Probes for the Diagnosis of Tumors and Image‐Guided Surgery

作者：Haidong Li, Dayeh Kim, Qichao Yao, Haoying Ge, Jeewon Chung, Jiangli Fan, Jingyun Wang, Xiaojun Peng, Juyoung Yoon · 发表于：Angewandte Chemie International Edition · 年份：2020 · DOI：10.1002/anie.202009796 · 被引用次数：367 · 研究领域：Nanoplatforms for cancer theranostics、Click Chemistry and Applications、Supramolecular Self-Assembly in Materials

Near-infrared (NIR) activatable fluorescent probes have been considered to be the effective edge tools for the investigation of cell biology and disease diagnosis because of their outstanding advantages. Related genes involved in tumor genesis and progression regulate the overexpression of certain enzymes. Owing to the distinctive characteristics of quick reaction time and favorable pharmacokinetics, enzyme-reactive NIR optical probes have shown great potential in the diagnosis of tumorigenesis and in image-guided intraoperative surgeries with high signal-to-noise ratios. In this review, we mainly summarize the latest advancements in enzyme-reactive NIR fluorescent probes from design strategy to biomedical application. Specifically, some challenges and prospects in this field are presented at the end of the review, which will be beneficial to innovatively construct new multifunctional fluorescent probes and actively promote their clinical transformation in the future.