Cascade reaction-mediated efficient ferroptosis synergizes with immunomodulation for high-performance cancer therapy

作者：Zhaowei Li, Long Rong · 发表于：Biomaterials Science · 年份：2020 · DOI：10.1039/d0bm01168a · 被引用次数：59 · 研究领域：Nanoplatforms for cancer theranostics、Extracellular vesicles in disease、Nanoparticle-Based Drug Delivery

NPs and induced ferroptosis, which promoted the release of tumor-associated antigens and generated an immunogenic tumor microenvironment (TME). Furthermore, immunomodulation was achieved by the polarization of tumor-associated macrophages (TAMs) induced by pH changes. The efficient ferroptosis and immunomodulation cooperatively paved the way for the inhibition of tumors. Beyond the inhibition of the primary tumor, the formulation could also efficiently provoke the immune response to exert a potent anticancer effect through combining with an immune checkpoint blockade. After being co-loaded with aCD47, the phagocytes could be stimulated and enhance the uptake efficiency of the tumor antigens to realize efficient immunotherapy with few abnormalities. Our approach thus offers a versatile formulation to realize the synergism of ferroptosis and immunomodulation/immunotherapy for high-performance cancer therapy.