Effects of multidisciplinary team on the outcomes of colorectal cancer patients with liver metastases

作者：Xingchen Li, Qichen Chen, Xinyu Bi, Jianjun Zhao, Zhiyu Li, Jianguo Zhou, Zhen Huang, Yefan Zhang, Rui Mao, Hong Zhao, Jianqiang Cai · 发表于：Annals of Palliative Medicine · 年份：2020 · DOI：10.21037/apm-20-193 · 被引用次数：18 · 研究领域：Global Cancer Incidence and Screening、Cancer Genomics and Diagnostics、Interdisciplinary Research and Collaboration

BACKGROUND: To evaluate the effect of a multidisciplinary team (MDT) treatment modality on outcomes of patients with colorectal cancer with liver metastases (CRLMs) in China. METHODS: We retrospectively identified 236 (MDT: 46, non-MDT: 190) patients who underwent liver resection or simultaneous resection for primary colorectal cancer and liver metastases with a curative intent for CRLMs at the National Cancer Center between January 2014 and June 2018. A 1:2 propensity score matching (PSM) analysis was used to adjust for differences in baseline characteristics between the MDT group and the non-MDT group. After the 1:2 PSM analysis, 46 patients were assigned to the MDT group, and 83 patients were assigned to the non-MDT group. All statistical analyses were performed using SPSS Statistics, version 22 (Armonk, NY, USA). Statistical significance was set at a 2-sided P<0.05. RESULTS: Before PSM analysis, compared to non-MDT patients, MDT patients had worse biological characteristics and were more likely to have node-positive primary tumors (80.4% vs. 63.2%), multiple liver metastases (73.9% vs. 50.5%), and liver metastases with a bilobar distribution (73.9% vs. 50.5%). However, MDT patients had a tendency towards better overall survival (OS) (P=0.169, median OS: 49.7 months vs. 35.2 months). After PSM analysis, no differences in clinicopathologic parameters were identified between the MDT group and the non-MDT group. Compared to non-MDT patients, MDT patients had a tendency toward...