CATP-8/P5A ATPase Regulates ER Processing of the DMA-1 Receptor for Dendritic Branching

作者：Zhi-Gang Feng, Yupeng Zhao, Tingting Li, Wang Nie, Xiaoyan Yang, Xinjian Wang, Jianguo Wu, Jun Liao, Yan Zou · 发表于：Cell Reports · 年份：2020 · DOI：10.1016/j.celrep.2020.108101 · 被引用次数：29 · 研究领域：Genetics, Aging, and Longevity in Model Organisms、Pancreatic function and diabetes、Circadian rhythm and melatonin

Dendrite morphogenesis is essential for a neuron to establish its receptive field and is, thus, the anatomical basis for the proper functioning of the nervous system. The molecular mechanisms governing dendrite branching are not fully understood. Using the multi-dendritic PVD neuron in the nematode Caenorhabditis elegans, we identify CATP-8/P5A ATPase as a key regulator of dendrite branching that controls the translocation of the DMA-1 receptor to the endoplasmic reticulum (ER). The specific signal peptide of DMA-1 and the ATPase activity of CATP-8 are essential for this process. Our results reveal that P5A ATPase may regulate protein translocation in the ER.