Histone deacetylase inhibitors promote epithelial-mesenchymal transition in Hepatocellular Carcinoma via AMPK-FOXO1-ULK1 signaling axis-mediated autophagy

作者：Qiang Xiao, Hao Liu, Hongsheng Wang, Meng-Ting Cao, Xiaojun Meng, Yali Xiang, Yaqin Zhang, Feng Shu, Qiu-Gui Zhang, Hong Shan, Guanmin Jiang · 发表于：Theranostics · 年份：2020 · DOI：10.7150/thno.47045 · 被引用次数：40 · 研究领域：Autophagy in Disease and Therapy、Histone Deacetylase Inhibitors Research、Sirtuins and Resveratrol in Medicine

We demonstrated that HDIs triggers FOXO1-dependent autophagy, which ultimately promotes EMT, limiting the clinical outcome of HDI-based therapies. Our study suggests that the combination of an HDI and a FOXO1 inhibitor is an effective therapeutic strategy for the treatment of HCC.