CDK4/6 inhibition promotes immune infiltration in ovarian cancer and synergizes with PD-1 blockade in a B cell-dependent manner

作者：Qian‐Feng Zhang, Jia Li, Kuo Jiang, Rui Wang, Junli Ge, Hong Yang, Shujuan Liu, Lintao Jia, Lei Wang, Biliang Chen · 发表于：Theranostics · 年份：2020 · 被引用次数：202 · 研究领域：Advanced Breast Cancer Therapies、Cancer Immunotherapy and Biomarkers、Cancer Mechanisms and Therapy

These findings suggest that combined treatment with CDK4/6i and anti-PD-1 antibody could improve the efficacy of anti-PD-1 therapy and hold great promise for the treatment of poorly immune-infiltrated ovarian cancer.