Hyperfols A and B: Two Highly Modified Polycyclic Polyprenylated Acylphloroglucinols from Hypericum perforatum

作者：Hua‐Yong Lou, Yanan Li, Ping Yi, Jun-you Jian, Zhan‐Xing Hu, Wei Gu, Lie‐Jun Huang, Yanmei Li, Chun‐Mao Yuan, Xiao‐Jiang Hao · 发表于：Organic Letters · 年份：2020 · DOI：10.1021/acs.orglett.0c02434 · 被引用次数：40 · 研究领域：Natural Compound Pharmacology Studies、Bioactive natural compounds、Bioactive Compounds and Antitumor Agents

Two novel polycyclic polyprenylated acylphloroglucinols (PPAPs), hyperfols A ( 1 ) and B ( 2 ), and two known biosynthetically related precursors ( 3 and 4 ) were isolated from Hypericum perforatum . Compound 1 possesses an unprecedented 2,3- seco -PPAP with a fused 5/5/9/5 tetracyclic skeleton, and 2 features a 30-norPPAP. Their structures were established by spectroscopic analysis, computer-assisted structure elucidation software, and electronic circular dichroism calculations. Moreover, compounds 1 and 4 exhibit significant cytotoxicity against human erythroleukemia cells by inducing cell apoptosis.