Malondialdehyde in Nasal Fluid: A Biomarker for Monitoring Asthma Control in Relation to Air Pollution Exposure

作者：Linchen He, Xiaoxing Cui, Zhen Li, Yanbo Teng, Karoline K. Barkjohn, Christina Norris, Lin Fang, Lili Lin, Qian Wang, Xiaojian Zhou, Jianguo Hong, Feng Li, Yinping Zhang, James J. Schauer, Marilyn Black, Michael Bergin, Junfeng Zhang · 发表于：Environmental Science & Technology · 年份：2020 · DOI：10.1021/acs.est.0c02558 · 被引用次数：42 · 研究领域：Air Quality and Health Impacts、Asthma and respiratory diseases、Air Quality Monitoring and Forecasting

Fine particulate matter (PM 2.5 ) and ozone (O 3 ) may exert oxidative damage in the nose, which is hypothesized to be associated with worsened asthma symptoms. This study, hence, is to explore whether an oxidative stress biomarker, malondialdehyde (MDA) in the nasal fluid, has the potential to aid personalized asthma control. In a panel study of 43 asthmatic children, 5–13 years old, each child was measured 4 times with a 2-week interval between consecutive clinic visits. At each visit, nasal fluid and urine samples were collected, and fractional exhaled nitric oxide (FeNO) was measured as a biomarker of pulmonary inflammation. In addition to nasal MDA, urinary MDA and 8-hydroxy-2′-deoxyguanosine (8-OHdG) were measured as biomarkers of systemic oxidative stress. We also assessed asthma symptoms using the Childhood Asthma-Control Test (C-ACT). We found that interquartile range (IQR) increases in 24 h average personal PM 2.5 exposure (22.2–33.5 μg/m 3 ), estimated 0 to 5 days prior to a clinic visit, were associated with increased nasal MDA concentrations by 38.6–54.9%. Similarly, IQR increases in 24 h average personal O 3 exposure (7.7–8.2 ppb) estimated 2 to 4 days prior were associated with increased nasal MDA by 22.1–69.4%. Only increased PM 2.5 exposure was associated with increased FeNO. Increased nasal MDA concentration was associated with decreased total and individual C-ACT scores, indicating worsening of asthma symptoms. However, no significant associations were obse...