T-cell tumour exclusion and immunotherapy resistance: a role for CAF targeting

作者：Christopher J. Hanley, Gareth J. Thomas · 发表于：British Journal of Cancer · 年份：2020 · DOI：10.1038/s41416-020-1020-6 · 被引用次数：51 · 研究领域：Cancer Immunotherapy and Biomarkers、Immunotherapy and Immune Responses、CAR-T cell therapy research

Recent studies have highlighted a major role for cancer-associated fibroblasts (CAFs) in promoting immunotherapy resistance by excluding T cells from tumours. Recently, we showed that CAFs can be effectively targeted by inhibiting the enzyme NOX4; this 'normalises' CAFs and overcomes immunotherapy resistance. Here we discuss our study and other strategies for CAF targeting.