Endothelial-to-Mesenchymal Transition: Role in Cardiac Fibrosis

作者：Weijia Cheng, Xiao Li, Dongling Liu, Chaochu Cui, Xianwei Wang · 发表于：Journal of Cardiovascular Pharmacology and Therapeutics · 年份：2020 · DOI：10.1177/1074248420952233 · 被引用次数：44 · 研究领域：Pulmonary Hypertension Research and Treatments、Cardiac Fibrosis and Remodeling、Congenital heart defects research

Endothelial-to-mesenchymal transition (EndMT) is a complex biological process by which endothelial cells lose their endothelial cell characteristics and acquire mesenchymal cell properties under certain physiological or pathological conditions. Recently, it has been found that EndMT plays an important role in the occurrence and development of fibrotic cardiovascular diseases. In this review, we first summarize the main induction pathways involved in EndMT process. In addition, we discuss the role of EndMT in fibrotic cardiovascular diseases and its potential implication in new therapeutic interventions.