Monacycliones G–K and ent -Gephyromycin A, Angucycline Derivatives from the Marine-Derived Streptomyces sp. HDN15129

作者：Yimin Chang, Li Xing, Chunxiao Sun, Shuang Liang, Tao Liu, Xiaomin Zhang, Tianjiao Zhu, Blaine A. Pfeifer, Qian Che, Guojian Zhang, Dehai Li · 发表于：Journal of Natural Products · 年份：2020 · DOI：10.1021/acs.jnatprod.0c00684 · 被引用次数：36 · 研究领域：Microbial Natural Products and Biosynthesis、Marine Sponges and Natural Products、Synthetic Organic Chemistry Methods

Six new angucycline derivatives, named monacycliones G–K ( 1 – 5 ) and ent -gephyromycin A ( 6 ), as well as three known ones ( 7 – 9 ) were discovered from the marine sediment-derived actinomycete Streptomyces sp. HDN15129 guided by Global Natural Products Social (GNPS) molecular networking. Structures including absolute configurations were elucidated by extensive NMR, MS, and ECD analyses. Among them, monacyclione G ( 1 ) possesses a unique scaffold featuring a xanthone core linked to the aminodeoxysugar ossamine, and monacycliones H–J ( 2 – 4 ) are rare examples of natural angucyclines with an S -methyl group. Monacycliones I and J ( 3 and 4 ) showed cytotoxic activity against multiple human cancer cell lines, with IC 50 values ranging from 3.5 to 10 μM.