Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders

作者：Autism Spectrum Disorder, Bipolar Disorder, Major Depressive Disorder, Obsessive-Compulsive Disorder, and Schizophrenia ENIGMA Working Groups, Yash Patel, Nadine Parker, Jean Shin, Derek Howard, Leon French, Sophia I. Thomopoulos, Elena Pozzi, Yoshinari Abe, Christoph Abé, Alan Anticevic, Martin Alda, André Alemán, Clara Alloza, Sílvia Alonso-Lana, Stephanie H. Ameis, Evdokia Anagnostou, Andrew A. McIntosh, Celso Arango, Paul D. Arnold, Philip Asherson, Francesca Assogna, Guillaume Auzias, Rosa Ayesa‐Arriola, Geor Bakker, Nerisa Banaj, Tobias Banaschewski, Cibele Edom Bandeira, Baranov Aa, Núria Bargalló, Claiton H.D. Bau, Sarah Baumeister, Bernhard T. Baune, Mark A. Bellgrove, Francesco Benedetti, Alessandro Bertolino, Premika S.W. Boedhoe, Marco P. Boks, Irene Bollettini, Caterina del Mar Bonnín, Tiana Borgers, Stefan Borgwardt, Daniel Brandeis, Brian P. Brennan, Jason Bruggemann, Robin Bülow, Geraldo F. Busatto, Sara Calderoni, Vince D. Calhoun, Rosa Calvo, Erick J. Canales‐Rodríguez, Dara M. Cannon, Vaughan J. Carr, Nicola G. Cascella, Mara Cercignani, Tiffany Chaim-Avancini, Anastasia Christakou, David Coghill, Annette Conzelmann, Benedicto Crespo‐Facorro, Ana I. Cubillo, Kathryn R. Cullen, Renata B. Cupertino, Eileen Daly, Udo Dannlowski, Christopher G. Davey, Damiaan Denys, Christine Deruelle, Annabella Di Giorgio, Erin W. Dickie, Danai Dima, Katharina Dohm, Stefan Ehrlich, Benjamin A. Ely, Tracy Erwin-Grabner, Thomas Ethofer, Damien A. Fair, Andreas J. Fallgatter, Stephen V. Faraone, Mar Fatjó‐Vilas, Jennifer Fedor, Kate D. Fitzgerald, Judith M. Ford, Thomas Frodl, Cynthia H.Y. Fu, Janice M. Fullerton, Matt C. Gabel, David C. Glahn, Gloria Roberts, Tinatin Yu. Gogberashvili, José Manuel Goikolea, Ian H. Gotlib, Roberto Goya‐Maldonado, Hans J. Grabe, Melissa J. Green, Eugênio H. Grevet, Nynke A. Groenewold, Dominik Grotegerd, Oliver Gruber, Patricia Gruner, Amalia Guerrero‐Pedraza, Raquel E. Gur, Ruben C. Gur, Shlomi Haar, Bartholomeus C. M. Haarman, Jan Haavik, Tim Hahn, Tomáš Hájek, Ben J. Harrison, Neil A. Harrison, Catharina A. Hartman, Heather C. Whalley, Dirk J. Heslenfeld, Derrek P. Hibar, Eva Hilland, Yoshiyuki Hirano, Tiffany C. Ho, Pieter J. Hoekstra, Liesbeth Hoekstra, Sarah Hohmann, L. E. Hong, Cyril Höschl, Marie F. Høvik, Fleur M. Howells, Igor Nenadić, Maria Jalbrzikowski, Anthony James, Joost Janssen, Fern Jaspers‐Fayer, Jian Xu, Rune Jonassen, Georgii Karkashadze, Joseph A. King, Tilo Kircher, Matthias Kirschner, Kathrin Koch, Peter Kochunov, Gregor Kohls, Kerstin Konrad, Bernd Krämer, Axel Krug, Jonna Kuntsi, Jun Soo Kwon, Mikael Landén, Nils Inge Landrø, Luisa Lázaro, И. С. Лебедева, Elisabeth J. Leehr, Sara Lera‐Miguel, Klaus‐Peter Lesch, Christine Löchner, Mário R. Louzã, Beatríz Luna, Astri J. Lundervold, Frank P. MacMaster, Luigi A. Maglanoc, Charles B. Malpas, Marı́a J. Portella, Rachel Marsh, Fiona M. Martyn, David Mataix‐Cols, Daniel H. Mathalon, Hazel McCarthy, Colm McDonald, Genevieve McPhilemy, Susanne Meinert, José M. Menchón, Luciano Minuzzi, Philip B. Mitchell, Carmen Moreno, Pedro Morgado, Filippo Muratori, Clodagh M. Murphy, Declan Murphy, Benson Mwangi, Leila Nabulsi, Akiko Nakagawa, Takashi Nakamae, Leyla S. Namazova-Baranova, Janardhanan C. Narayanaswamy, Neda Jahanshad, Danai D. Nguyen, Rosa Nicolau, Ruth Tuura, Kirsten O’Hearn, Jaap Oosterlaan, Nils Opel, Roel A. Ophoff, Bob Oranje, Víctor Ortiz‐García de la Foz, Bronwyn J. Overs, Yannis Paloyelis, Christos Pantelis, Mara Parellada, Paul Pauli, Maria Picó‐Pérez, Felipe Almeida Picon, Fabrizio Piras, Federica Piras, Kerstin Jessica Plessen, Edith Pomarol‐Clotet, Adrian Preda, Olga Puig, Yann Quidé, Joaquim Raduà, Josep Antoni Ramos‐Quiroga, Paul E. Rasser, Lisa Rauer, Janardhan Reddy, Ronny Redlich, Andreas Reif, Liesbeth Reneman, Jonathan Repple, Alessandra Retico, Vanesa Richarte, Anja Richter, Pedro G. P. Rosa, Katya Rubia, Ryota Hashimoto, Matthew D. Sacchet, Raymond Salvador, Javier Santonja, Kelvin Sarink, Salvador Sarró, Theodore D. Satterthwaite, Akira Sawa, Ulrich Schall, Peter R. Schofield, Anouk Schrantee, Jochen Seitz, Maurício H. Serpa, Esther Setién‐Suero, Philip E. Shaw, Devon Shook, Timothy J. Silk, Kang Sim, Schmitt Simon, Blair Simpson, Aditya Singh, Antonín Škoch, Norbert Skokauskas, Jair C. Soares, Noam Soreni, Carles Soriano‐Mas, Gianfranco Spalletta, Filip Španiel, Stephen M. Lawrie, Emily Stern, S. Evelyn Stewart, Yoichiro Takayanagi, Henk Temmingh, David F. Tolin, David Tomeček, Diana Tordesillas‐Gutiérrez, Michela Tosetti, Anne Uhlmann, Thérèse van Amelsvoort, Nic J. A. van der Wee, Steven J.A. van der Werff, Neeltje E. M. van Haren, Guido van Wingen, Alasdair Vance, Javier Vázquez-Bourgón, Daniela Vecchio, Ganesan Venkatasubramanian, Eduard Vieta, Óscar Vilarroya, Yolanda Vives‐Gilabert, Aristotle N. Voineskos, Henry Völzke, Georg G. von Polier, Esther Walton, Thomas W. Weickert, Cynthia Shannon Weickert, Andrea Weideman, Katharina Wittfeld, Daniel H. Wolf, Mon-Ju Wu, Tony T. Yang, Kun Yang, Yuliya Yoncheva, Je‐Yeon Yun, Yuqi Cheng, Marcus V. Zanetti, Georg Ziegler, Barbara Franke, Martine Hoogman, Jan K. Buitelaar, Daan van Rooij, Ole A. Andreassen, Christopher R. K. Ching, Dick J. Veltman, Lianne Schmaal, Dan J. Stein, Odile A. van den Heuvel, Jessica A. Turner, Theo G.M. van Erp, Zdenka Pausová, Paul M. Thompson, Tomáš Paus · 发表于：JAMA Psychiatry · 年份：2020 · DOI：10.1001/jamapsychiatry.2020.2694 · 被引用次数：266 · 研究领域：Functional Brain Connectivity Studies、Tryptophan and brain disorders、Genetic Associations and Epidemiology

IMPORTANCE: Large-scale neuroimaging studies have revealed group differences in cortical thickness across many psychiatric disorders. The underlying neurobiology behind these differences is not well understood. OBJECTIVE: To determine neurobiologic correlates of group differences in cortical thickness between cases and controls in 6 disorders: attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BD), major depressive disorder (MDD), obsessive-compulsive disorder (OCD), and schizophrenia. DESIGN, SETTING, AND PARTICIPANTS: Profiles of group differences in cortical thickness between cases and controls were generated using T1-weighted magnetic resonance images. Similarity between interregional profiles of cell-specific gene expression and those in the group differences in cortical thickness were investigated in each disorder. Next, principal component analysis was used to reveal a shared profile of group difference in thickness across the disorders. Analysis for gene coexpression, clustering, and enrichment for genes associated with these disorders were conducted. Data analysis was conducted between June and December 2019. The analysis included 145 cohorts across 6 psychiatric disorders drawn from the ENIGMA consortium. The numbers of cases and controls in each of the 6 disorders were as follows: ADHD: 1814 and 1602; ASD: 1748 and 1770; BD: 1547 and 3405; MDD: 2658 and 3572; OCD: 2266 and 2007; and schizophrenia: 2688 and 3244. MAIN ...