Electrochemical decarboxylative C3 alkylation of quinoxalin-2(1 H )-ones with N -hydroxyphthalimide esters

作者：Kaikai Niu, Lingyun Song, Yanke Hao, Yuxiu Liu, Qingmin Wang · 发表于：Chemical Communications · 年份：2020 · DOI：10.1039/d0cc05391k · 被引用次数：96 · 研究领域：Radical Photochemical Reactions、CO2 Reduction Techniques and Catalysts、Oxidative Organic Chemistry Reactions

We have developed a protocol for electrochemical decarboxylative C3 alkylation of a wide range of quinoxalin-2(1H)-ones under metal- and additive-free conditions. N-Hydroxyphthalimide esters derived from chain, cyclic, primary, secondary, and tertiary carboxylic acids with a broad scope proved to be suitable substrates. This operationally simple protocol performed in an undivided cell under constant-current conditions is suitable for late-stage functionalization of quinoxalin-2(1H)-ones. The reactions can even be carried out with a 3 V battery as a power source, which demonstrates that organic electrosynthesis can be accomplished without the need for specialized equipment.